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It has been reported that oxidative stress, Mediated by reactive oxygen race, Induces ET 1 expression in vascular smooth muscle cells31 33 and that 8 IPG F2a energizes the secretion of ET 1 by endothelial cells.8,34 what is more, An increased aqueous humour concentration of TGF 1 and 8 IsoPGF2a has recently been documented in XFS.5,35 37 considering that 8 IsoPGF2a, A marker of the oxidative concerns, promotes ET 1 expression of endothelial cells8,34 it is reasonable to hypothesise that oxidative stress induces an increase of the aqueous humour ET 1 attention in XFS by increasing 8 IsoPGF2a concurrently in the aqueous. Furthermore it has been reported that oxidative stress and 8 IsoPGF2a induce TGF 1 synthesis.38,39 TGF 1 might further stimulate the synthesis of ET 1.40 necessary, Argon unit trabeculoplasty, A procedure regarding increased cheap ravens jerseys formation of free radicals in the anterior segment of the eye,21 caused a 7 12 fold increase in ET 1 actions in the aqueous humour of rabbits.18 20 This increase was immediate and was related with an increase of IOP.19 subsequently, It is reasonable to assume that the increased levels of TGF 1 in the aqueous humour of XFS patients may amplify the effect of oxidative stress on aqueous ET 1 concentration.